Genitourinary Cancers Clinical Trials & Research at Providence Medical Group

Genitourinary (GU) cancers encompass a diverse group of malignancies affecting the urinary system and the male reproductive organs. This category includes cancers of the bladder, kidneys, prostate, testicles, and penis. These cancers vary widely in their biology, prognosis, and treatment options, making clinical research crucial for improving patient outcomes.

Clinical trials are fundamental to the advancement of GU cancer treatment. These studies investigate new therapies and interventions, aiming to enhance the effectiveness and reduce the side effects of existing treatments. They encompass a wide range of approaches, including novel drug therapies, immunotherapies, targeted treatments, surgical techniques, and combinations of these modalities.

Prostate/Endometrial and Pancreatic cancer studies are also included in these trials.

Pancreatic cancer develops in the pancreatic ductal, acinar, and islet cells. Most pancreatic cancers are adenocarcinoma of pancreatic ductal (PDA) origin. Pancreatic cancer accounts for about 3 percent of all cancers in the U.S. Risk factors that can be changed include tobacco use, obesity, and workplace exposure to certain chemicals.

Providence Medical Group is currently enrolling patients for the following genitourinary cancers clinical trials:


A Phase 1b/2, Multicenter, OpenLabel Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants With Advanced Solid Tumors (EMD Serono MS202329-0010 PROCEADE)

Treatment agent: Anti-CEACAM5 Antibody-Drug Conjugate M9140

Physician: Ian Anderson, MD
Study Coordinator: Sam Hansen // Samantha.Hansen@stjoe.org // 707-521-3830
Study Resources: Study Details | Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor) | ClinicalTrials.gov
Sponsor: EMD Serono Research & Development Institute, Inc
Location: Providence Cancer Center, Santa Rosa, CA


Study to Assess the ATR Kinase Inhibitor ART0380 Administered Orally as Monotherapy and in Combination to Patients with Advanced or Metastatic Solid Tumors

Treatment agent: ART0380 + Irinotecan
Physician: Ian Anderson, MD
Study Coordinator: Melissa Ulrich // melissa.ulrich@providence.org // 707-521-3830
Study Resources: Study Details | A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors | ClinicalTrials.gov
Sponsor: Artios Pharma Ltd.
Location: Providence Cancer Center, Santa Rosa, CA


A study of Dato-Dxd as monotherapy and in combination with anti-cancer agents in patients with advanced solid tumors: AZ D926UC00001 Tropion Pan-Tumor 03

Treatment agent: Datopotamab Deruxtecan- an ADC comprised of a recombinant humanized anti-TROP2 IgG1 mAb
Physician: Ian Anderson, MD
Study Coordinator: Camille Shaffer // camille.shaffer@stjoe.org // 707-521-3830
Study Resources: Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03) - Full Text View - ClinicalTrials.gov
Sponsor: AstraZeneca
Location: Providence Cancer Center, Santa Rosa, CA


A Randomized, Open-Label, Phase 2/3 Study of Datopotamab Deruxtecan (Dato-DXd) plus Carboplatin or Cisplatin versus Gemcitabine plus Carboplatin or Cisplatin in Participants with Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC) who Progressed During or After Enfortumab Vedotin (EV) plus Pembrolizumab Combination Treatment - TROPION-Urothelial03 (TU03)

Treatment agent: Datopotamab Deruxtecan (Dato-DXd) + Carboplatin/Cisplatin vs Gemcitabine + Carboplatin/Cisplatin
Physician: Dr Wes Shen-Lin Lee, MD | Hematology in Santa Rosa
Study Coordinator: Davina Montelongo // Davina.Montelongo@providence.org // 707-521-3830
Study Resources: Study Details | NCT07129993 | Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma | ClinicalTrials.gov
Sponsor: Daiichi Sankyo
Location: Providence Cancer Center, Santa Rosa, CA

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